Proposed diagnostic strategy using the expert-independent classification and modular design of the B-CLPD panel. The infiltration of sample by a B-CLPD is assessed using tube 1 first. Patients presenting with a high pretest (clinical, basic laboratory, cytology, or after evaluating tube 1) likelihood for a CLL, MCL, or FL should be evaluated as next step using tubes 1 and 2 only. If the diagnosis of 1 of those 3 entities is made, no further testing is recommended. If neither CLL, nor MCL, nor FL is diagnosed, the additional evaluation of tubes 3 to 5 is advisable. Patients who are not suspected of CLL, MCL, or FL should be directly tested with the full panel. Percentages in squares reflect PPV by entity and testing strategy.