Molecular changes induced in XABCL in vivo. (A) Mice bearing XABCLs TC389 and TC929 (n = 3 mice per group) were treated with solvent, navtemadlin, or idasanutlin (Idasa) for 3 days. Tumors were harvested for RPPA analysis as described in “Methods.” Proteins with significant changes (adjusted P < .05) induced by both MDM2is in both models are shown in the heatmap. (B) Change in mRNA induced during B-lymphocyte reprogramming after EBV infection. The data were downloaded from http://ebv-b.helmholtz-muenchen.de/. Heatmap shows genes whose proteins were included in panel A.