Figure 5.
Microlyse attenuates the symptoms of acute TTP in Adamts13−/− mice. (A) Experimental setup; 7 days prior to TTP challenge, baseline characteristics (platelet counts, LDH activity, and PAI-1 levels were determined). Mice were challenged with rhVWF (2250 IU/kg). After 15 minutes, mice were IV injected with saline or treatment compounds. Experimental outcomes were determined either 15 minutes after treatment (t = 30 min; tail-clip) or 24 hours after TTP induction. (B) Platelet counts. (C) LDH activity. (D) PAI-1 levels. (E) VWF antigen levels 24 hours after administration of saline, Microlyse, or Neg-Microlyse (416 nM). (F,G) Platelet counts and bleeding times 15 minutes after administration of saline, Microlyse, or Neg-Microlyse (416 nM). Data are represented as scatterplots with medians. *P < .05, **P < .005, ***P < .0005, ****P < .0001, compared with saline by 1-way ANOVA with post hoc Dunnett’s multiple comparison test.

Microlyse attenuates the symptoms of acute TTP in Adamts13−/− mice. (A) Experimental setup; 7 days prior to TTP challenge, baseline characteristics (platelet counts, LDH activity, and PAI-1 levels were determined). Mice were challenged with rhVWF (2250 IU/kg). After 15 minutes, mice were IV injected with saline or treatment compounds. Experimental outcomes were determined either 15 minutes after treatment (t = 30 min; tail-clip) or 24 hours after TTP induction. (B) Platelet counts. (C) LDH activity. (D) PAI-1 levels. (E) VWF antigen levels 24 hours after administration of saline, Microlyse, or Neg-Microlyse (416 nM). (F,G) Platelet counts and bleeding times 15 minutes after administration of saline, Microlyse, or Neg-Microlyse (416 nM). Data are represented as scatterplots with medians. *P < .05, **P < .005, ***P < .0005, ****P < .0001, compared with saline by 1-way ANOVA with post hoc Dunnett’s multiple comparison test.

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