Gene expression analysis of the ATO-resistant cell lines reveals dysregulation of cellular metabolism. (A) Pie chart representing the dysregulated genes in the in-house–generated ATO-resistant NB4EV-AsR1 and UF1 cell lines compared with parental NB4 naïve cell line. (B) Heatmap highlighting gene signature of NB4 naïve (duplicate) in-house–generated ATO-resistant cell line (duplicate) and the 8 unmatched samples from patients with newly diagnosed and relapsed APL (primary cell data was previously reported and was adapted from Chendamari et al).²¹  (C) Heatmap representing NB4 naïve, ATO-resistant NB4EV-AsR1, and UF1 cell line genes involved in glycolytic and mitochondrial metabolism.