Distribution of clonal hematopoietic mutations in studied cohorts. Clonal hematopoietic mutations were identified from sequencing of whole genomes (COPDGene, additional TOPMed cohorts) or exomes (ICGN-EOCOPD, UK Biobank) found in samples of peripheral blood. Shown are the 10 most frequently mutated genes in COPDGene. N represents the number of CHIP carriers identified in each cohort. In patients with multiple mutations, the mutated gene with the largest variant allele frequency is shown.