Kaplan-Meier estimates of time to true deterioration. (A) QLQ-C30 global health status/QoL. (B) QLQ-C30 physical functioning. (C) QLQ-C30 role functioning. (D) QLQ-C30 emotional functioning. (E) QLQ-C30 cognitive functioning. (F) QLQ-C30 social functioning. Time to true deterioration is defined as the time to first onset of 10 or more decrease from baseline with confirmation under right-censoring rule (the last observation). *Two-sided P value based on log-rank test.