Characteristics of patients with DDX41 mutation. (A) Representation of DDX41 variants detected, positioned on the DDX41 protein and its functional domains. (B) Patterns of the mutations identified in the cohort of 33 patients with DDX41 mutation. The number reported in the box represents the VAF of each mutation. (C-D) Kaplan-Meier survival curves in 10 patients with mDDX41 AML compared with (C) 40 patients with inv 16 AML and (D) 27 patient with t(8;21) AML. CTD, C-terminal domain; ZFD, zinc finger domain; Δ, second mutation.