Box plot showing the age distribution, fibrinogen level, platelet count, antithrombin level, and PC activity at the time of diagnosis according to patient outcome (with or without amputation and/or skin graft). The box represents the interquartile (25th to 75th percentiles) range. The horizontal line in the box represents the median. The whiskers represent the maximum and minimum values (A) for case series patients and (B) for all patients (cases series and literatures review cases). The P value was estimated using Mann-Whitney nonparametric U test or Student t test. *P < .05; **P < .01; **P < .001.