The prognostic significance of high-risk aberrations that are present at baseline or at relapse. (A) Proportion of patients with high-risk aberrations present at diagnosis and at relapse. (B-E) Kaplan-Meier curves estimates for survival in patients with the presence of high-risk aberrations at diagnosis (B,D) and patients with the presence of high-risk aberrations at relapse (C,E). Different landmarks are used: OS from diagnosis (B,C) and OS from relapse (D,E). (F) Kaplan-Meier curves in patients with high-risk aberrations at diagnosis.