SNV overview of important MM MRD genes. Functional domains are shown for each gene; mutated positions are represented by colored lollipop marks (red, single nucleotide change; blue, splice site/nonsense mutation). (A) Mutations in genes potentially useful in clinics are suggested for preclinical studies. Interacting drugs are given on the right. (B) Genes identified as drivers without assigned treatment and gene FRMPD3 are schematically shown. (C) Kaplan-Meier curve showing gene FRMPD3 that is the only shared gene with significant PFS association. PI, proteasome inhibitor.