Mutation profile of the MRD cohort. (A) Recurrently mutated genes and functionally important hits. Patients are depicted as columns; genes are depicted as rows. Previously identified MM associated genes (supplemental Table 3) are highlighted in red rectangles; star symbols indicate potentially actionable targets. Total number of single nucleotide variants (SNVs) in particular patients is given on the top. Driver frequencies from other studies were obtained from 5 papers.^3–7  (B-C) Kaplan-Meier curves showing association of PFS with RAS-related pathways. Pathways KRAS.600_UP.V1_UP included synthetic lethal partners of oncogenic KRAS. Ras protein signal transduction pathway is a series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. List of genes included in respective pathways is provided below each graph. FDR, false discovery rate; mut, mutated; wt, wild type.