Blood counts by age in subjects with SDS. A piecewise regression model (green shaded area) was used to determine the association between blood counts and age, allowing for a potential breakpoint for 2114 blood counts from 119 subjects. The locally estimated scatterplot smoothing (LOESS) curve is shown in purple. LogANC (A), hemoglobin (B), and log platelet count (C) as a function of age.