Association of ASNS methylation status with cytogenetic abnormalities in childhood T-ALL. (A) Association of cytogenetic abnormalities with ASNS methylation status in childhood T-ALL. Red, yellow, and blue columns indicate ASNS highly methylated (>66.7%), intermediately methylated (33.3%-66.7%), and weakly methylated (<33.3%) cases, respectively. (B) Association of cytogenetic abnormalities with ASNS gene expression level in childhood T-ALL. Asterisks indicate significance in the Mann-Whitney U test. **0.001 < P < .01; *0.01 < P < .05. (C) Comparison of ASNS methylation status between childhood T-ALL cases with and without NOTCH1/FBXW7 mutations. The P value in the χ² test is shown.