Figure 4.
![ASNS methylation status in pediatric patients with T-ALL. (A) Correlation between methylation level of ASNS and that of 7 genes located in the 7q21 imprinted gene cluster in 77 childhood T-ALL samples of the TCCSG and JACLS cohorts (DNA Data Bank of Japan [JGAS00000000138]).23 The vertical axes indicate mean percent methylation of ASNS, and the horizontal axes indicate mean percent methylation of each gene. The correlation coefficients and P values in the Spearman correlation test are indicated. (B) Association of ASNS methylation status with ASNS gene expression in 77 childhood T-ALL samples of the TCCSG and JACLS cohorts. Correlation coefficient and P value in the Spearman correlation test are shown.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/6/1/10.1182_bloodadvances.2021004271/4/advancesadv2021004271f4.png?Expires=1720282445&Signature=uaevYywrjbrVLKWWN-2Wy9VX5FrmptkIj4j64ZI01~0M2X0JtmhsycjT68jkcnuy94QnbW6oQunKipTjHS4KFhKwag6ArRu6RBKB7xPiCFw1G0YBREwlR0q334~JH2mDxc7ZmbLu1ZUdeKs~ilHnS0kqOl0OIEL7GBrhXK2z54DQNSdeG~Tf6rrxqi-75rCIQFE3ft6LmQniSn1uc0ag84GD0gGegsDw437NHicWeoF3IJwySy3JJh77tzBbjQ~IIDbLM1c5-um6lgODdOY6gSFrAqgqYjLs0Bo5TVdRmaX~iM8ppjSzaoS8v2tRNxylMa-vLDIcLiSMcVtqckh6ag__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
ASNS methylation status in pediatric patients with T-ALL. (A) Correlation between methylation level of ASNS and that of 7 genes located in the 7q21 imprinted gene cluster in 77 childhood T-ALL samples of the TCCSG and JACLS cohorts (DNA Data Bank of Japan [JGAS00000000138]).23 The vertical axes indicate mean percent methylation of ASNS, and the horizontal axes indicate mean percent methylation of each gene. The correlation coefficients and P values in the Spearman correlation test are indicated. (B) Association of ASNS methylation status with ASNS gene expression in 77 childhood T-ALL samples of the TCCSG and JACLS cohorts. Correlation coefficient and P value in the Spearman correlation test are shown.