Schematic view of mutations in recurrently mutated signaling pathways in CTCLs. CTCL harbors recurrent mutations that are predicted to affect (A) T-cell activation/NF-κB signaling, (B) JAK/STAT signaling, (C) MAPK signaling, and (D) chromatin modifications. SNV, single nucleotide variation. Adapted from Park et al 2017. Used with permission from the American Society of Hematology.