Fusion transcripts in adult and pediatric relapsed AML. Circos plots presenting gene fusion transcripts detected at relapse and in PR samples in adult (left) and pediatric (right) AML cases. Ribbon widths are proportional to the frequency of a fusion event among the respective patient cohort. Fusion transcripts that were gained at relapse or in PR samples are highlighted in red. In addition, one of the RUNX1-RUNX1T1 fusions in pediatric AML was solely detected at relapse. *2.1%; ¤4.3%; fs, frameshift.