CBL structure and KMT2A-CBL rearrangements. (A) Structure of the CBL protein and its domains: 4-helix bundle (4H), EF-hand-calcium binding (EF), SRC homology 2 (SH2), RING finger (RF), proline-rich domain (PR), and ubiquitin-associated domain (UBA). Phosphorylation sites (P) and predicted protein breakpoints for each patient are also represented. (B) Schematic representation of KMT2A and CBL genes with the breakpoint for each patient.