Inhibition of GSDMD with disulfiram abrogates NET formation and reduces sepsis severity. During sepsis, activated neutrophils release neutrophil granule components and NETs. NETs aggravate tissue injury and may lead to death resulting from sepsis. GSDMD is proteolytically activated by neutrophil proteases during NETosis and plays a pivotal role in the generation of NETs. Disulfiram inhibits GSDMD and abrogates NET formation, thus reducing sepsis lethality. KO, knockout.