PFS probability. (A) Overall PFS, (B) PFS by complex karyotype, (C) by complex karyotype with 3-4 chromosomal lesions and with ≥5 chromosomal lesions (pairwise comparisons: complex karyotype ≥5 lesions vs 1-2 lesions/normal/del13q [P = .121], complex karyotype ≥5 lesions vs complex karyotype 3-4 lesions [P = .550], complex karyotype 3-4 lesions vs 1-2 lesions/normal/del13q [P = .006]), and (D) by TP53 disruption and complex karyotype (pairwise comparisons: TP53 disrupted vs complex karyotype and TP53 wild type [WT] [P = .667], TP53 disrupted vs other [P = .097], complex karyotype and TP53 WT vs other [P = .026]).