PFS and EFS stratified by CIRS3⁺ and age. PFS (A) and EFS (B) of the whole population according to CIRS3⁺; PFS (C) and EFS (D) in patients <65 years according to CIRS3⁺; PFS (E) and EFS (F) in patients ≥65 years according to CIRS3⁺.