IGHV and trisomy 12 jointly affect interferon signaling through STAT2. (A) Visualization of fitted adaptive L1 (lasso) regularization multivariate models using IGHV status, mutations, and copy-number variations. The z scores of STAT2 protein expression are shown in the scatterplot at the bottom. The heatmap in the middle shows the predictor values, with black indicating the presence of mutation or copy-number variation. The model coefficients (averaged over 50 bootstrap samples) are shown by horizontal bars on the left. Only the features that were selected in all bootstrap samples are shown. (B) Analogous to A, for multivariate models using RNA and protein expression values, which are shown in the heatmap. (C) STAT2 protein and RNA expression stratified by IGHV and trisomy 12 status. (D) Cancer hallmark pathways enriched for RNAs and proteins associated with STAT2 protein expression after blocking for trisomy 12 and IGHV mutational status. (E) Associations between STAT2 protein expression and 2 interferon-induced genes, OAS2 and IFI44. (F) OAS2 and IFI44 RNA expression stratified by IGHV and trisomy 12 status.