Protein expression in trisomy 12 CLL. (A) Number of differentially expressed proteins encoded by chromosome 12 genes (red) and genes on other chromosomes (blue). (B) Gene set enrichment analysis of differentially expressed genes (FDR = 5%). (C) Heatmaps of expression Z score of differentially expressed proteins annotated as BCR or PI3K-AKT-MTOR signaling pathway components in samples with and without trisomy 12. (D) Volcano plot of differential protein expression. (E) Normalized expression values for selected proteins. (F) A circular heatmap plot showing the protein expression (outer layer) and RNA expression (inner layer) of genes encoded on chromosome 12 in patient samples with and without trisomy 12. The 2 tracks in the middle indicate the differential expression call (summarized across samples) at the protein and RNA levels. Genes are ordered by genomic coordinates on chromosome 12.