Global protein and RNA expression in CLL. (A) Distribution of Pearson’s correlation coefficient of mRNA and protein expression across 91 patient samples (main cohort). (B) Scatterplots comparing mRNA and protein expression (log₂-transformed and median-normalized mRNA and protein intensities) for ZAP70, CD22, and CD79A. Each point represents a patient sample. P values and coefficients are from Pearson’s correlation tests. (C) Scatterplots showing PC analyses based on the expression of all quantified proteins. (D) Heatmap visualization of the Pearson correlation coefficients for all samples, calculated from the expression values of all detected proteins. Matrix rows and columns are ordered according to hierarchical clustering. (E) Number of differentially expressed proteins (FDR = 5%, Benjamini-Hochberg procedure) in the main cohort for individual disease drivers in CLL.