![Dual anti–TNF-α and IL-6R blockade mitigated acute GVHD without interfering with the graft-versus-tumor effect in two different mouse models (major histocompatibility complex [MHC]–mismatch model BALB/c into C57BL/6 and minor mismatch model B10.D2 into diet-induced obese [DIO] BALB/c recipients). Professional illustration by Patrick Lane, ScEYEnce Studios.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/138/24/10.1182_blood.2021013772/5/bloodbld2021013772cf1.png?Expires=1722427952&Signature=KzErDjzBWNIcP22v~tNIQwYwNtwBorIvs5KIHSD1M2626t~TCmzIK7UOCH-dTI9q4S0es39uwOk1Y6Rmg5C77KinXiVT57jAEyjAttrwNio1RdKEu9lK9ev9j9VLMlQUggLeFVcP06m6SqNlrbaVMLkoRxUSJNCRlb786PGv8daaUpsVjpOrmGzwOdTmdjIB-zJQHcnnyhtgOfggZyX30zd7I593KPp~WqZYr9Yw3ibZzUgKVSFy2e4bcfSv4zWuXsVRO5aUe0mkhD0KRKmxoY5sB9irv7ZcGGpddavGiekzI~txSzJ8zYU4waxdj3GE4KBxW2LzqYk0ilUcUR1pdw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Dual anti–TNF-α and IL-6R blockade mitigated acute GVHD without interfering with the graft-versus-tumor effect in two different mouse models (major histocompatibility complex [MHC]–mismatch model BALB/c into C57BL/6 and minor mismatch model B10.D2 into diet-induced obese [DIO] BALB/c recipients). Professional illustration by Patrick Lane, ScEYEnce Studios.