Key relationships between immune defects and oncogenesis. General relationships are shown in A, and key relationships specific to the indicated diseases are shown in B-H. Yellow boxes denote key immunologic defects observed in HIV/AIDS and/or IEI; green boxes denote secondary defects; orange boxes denote infectious agents that contribute to malignancies in immunodeficiency; purple ovals show the principal malignancies associated with the immune defects. DC, dendritic cell; HHV-8, human herpesvirus 8.