NUDT15 variant frequency in patients with SMNs after ALL treatment. Comparisons of the frequency of NUDT15 variant cases between the SMN cohort and gnomAD database are shown. Six (42.9%) of 14 patients with SMNs after ALL treatment had NUDT15 heterozygous variants, whereas prevalence in the general East Asian population in the gnomAD database was 19.7%. (P = .042). WT, wild type.