Figure 4.
Identification of potential regulatory lncRNAs by integrating transcriptome and chromatin accessibility during erythroid differentiation. Clustering results of mRNAs (A) and lncRNAs (B). (C) Top 10 stage-specific lncRNAs expressed during erythroid differentiation. (D) LncRNAs differentially expressed between adjacent stages during erythroid differentiation. (E) The number of intersecting differentially expressed lncRNAs and the accessible chromatin between the MEP cell and EB stage. Bar plot on the left shows the number of differentially expressed lncRNAs and genes between MEP cell and EB and the number of specific lncRNAs in MEP and EB. The dot plot (bottom right) connected by solid lines represents different intersecting points. The bar plot (top right) represents the number of intersections. (F) The expression of lncRNAs with potential regulatory functions at the MEP cell and EB stages. DANCR is highly expressed at MEP cell stage. UCA1, CYTOR, LINC01133, LINC01128, and PCED1B-AS1 are highly expressed at EB stage.

Identification of potential regulatory lncRNAs by integrating transcriptome and chromatin accessibility during erythroid differentiation. Clustering results of mRNAs (A) and lncRNAs (B). (C) Top 10 stage-specific lncRNAs expressed during erythroid differentiation. (D) LncRNAs differentially expressed between adjacent stages during erythroid differentiation. (E) The number of intersecting differentially expressed lncRNAs and the accessible chromatin between the MEP cell and EB stage. Bar plot on the left shows the number of differentially expressed lncRNAs and genes between MEP cell and EB and the number of specific lncRNAs in MEP and EB. The dot plot (bottom right) connected by solid lines represents different intersecting points. The bar plot (top right) represents the number of intersections. (F) The expression of lncRNAs with potential regulatory functions at the MEP cell and EB stages. DANCR is highly expressed at MEP cell stage. UCA1, CYTOR, LINC01133, LINC01128, and PCED1B-AS1 are highly expressed at EB stage.

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