Transcriptional factors and hub gene identification through chromatin accessibility enrichment analysis and weighted gene coexpression network analysis. TF motif enrichment of ATAC-seq peaks during erythroid differentiation. (A) TFs specifically enriched at each stage during erythroid differentiation. (B) TFs enriched at differential peaks. (Some of the TFs are shown in the figure according to their enrichment score). The size of the circle represents the −log P value, which indicates the significance of TF motif enrichment. The color of circle represents the expression (A, FPKM) and differential fold change (B, log2FC) of TFs. (C) Gene cluster dendrogram obtained through linkage hierarchical clustering. The colorful lines below the tree show the modules that were calculated by Dynamic Tree Cutting. (D) The relationships between module and cell type. Each row represents a module eigengene, and each column corresponds to a trait. Each box contains the corresponding correlations and P value. The colors in the figure are based on the correlations. Expression of hub genes in EB, each shown by its significant module: the turquoise module (E) and the black module (F).