Figure 6.
![Gene set enrichment analysis shows increase in IFN-I production in BM pDCs of St3gal1MK−/− mice. (A) Dot plot summarizing Gene Set Enrichment Analysis statistics (P adjusted values [p-adj], normalized enrichment scores [NES], and set size) of IFN and IFN-α/β Reactome pathways comparing combined pDC clusters (1, 2, 11, and 12, also show discretely) with non-pDC clusters. Positive (normalized) enrichment scores indicate increased enrichment in St3gal1MK−/−clusters. (B) Representative enrichment plots of IFN gene sets from combined pDC clusters. (C) A heat map of IFN and IFN-α/β reactome genes of each cluster. KO, knockout; WT, wild type.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/138/23/10.1182_blood.2020008238/3/bloodbld2020008238f6.png?Expires=1722679986&Signature=tDE25qicC7sCt9~yaw7dQgSv-wZKYInBYuefSe94UlfRr0HbMbMi9XFVoWxnckJlt2893TRCVNV-8pv8hP2ZzIXQP--lFNotv4t063xdb6ZQoE8Ya5pRHkDaGuJgwpZ~kZlZa1owSzU~6exTApxfe-sg9knNBv3ITN~N3E1m1eFRibGIv-~rO5PyVfe985~mAg264kBRl6cgrYw-pSO7RiNN3VrI~4HP0TKKo9MV~NmdEOIsa6cyRhYSezn4WRn48quGSQ2LmRJ8XGEPkzo3TnkqEG4XaQSu1-mlv2NUTNQI7kAqzm-QE0QJHWkggLOM4tn6dmBzlX--lE1cUdEwjw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Gene set enrichment analysis shows increase in IFN-I production in BM pDCs of St3gal1MK−/− mice. (A) Dot plot summarizing Gene Set Enrichment Analysis statistics (P adjusted values [p-adj], normalized enrichment scores [NES], and set size) of IFN and IFN-α/β Reactome pathways comparing combined pDC clusters (1, 2, 11, and 12, also show discretely) with non-pDC clusters. Positive (normalized) enrichment scores indicate increased enrichment in St3gal1MK−/−clusters. (B) Representative enrichment plots of IFN gene sets from combined pDC clusters. (C) A heat map of IFN and IFN-α/β reactome genes of each cluster. KO, knockout; WT, wild type.