Survival of the validation cohort. Kaplan-Meier plots of OS from first progression, all patients (A); OS from first progression among patients treated with BR only (B); OS from first progression in patients treated with R-CHOP or R-CVP only (C); and OS from first progression among patients who underwent ASCT consolidation in first remission only (D); all categorized by duration of first remission. In panel D, n = 42 treated with R-CHOP/R-CVP; n = 10 treated with BR.