Net T-cell responses by scheduled time point. CD4⁺ and CD8⁺ net responses to pool-1 peptides in pediatric and young adult patients with r/r B-ALL (A,C) and adult patients with r/r DLBCL (B,D). Patients with sustained CR/CR with incomplete blood count recovery (CRi) or CR/partial response (PR) are indicated by solid color circles and are color-coded by scheduled time point for assessment. Negative net response data represent patients whose posttreatment T-cell responses were lower than the negative control (dimethylsulfoxide DMSO).