Transport of Fe3+ iron into cells on transferrin via the TFRC transferrin receptor and reduction of Fe3+ in the lysosome to Fe2+, either by STEAP3 or by CYB561A3. The divalent metal transporter DMT1 transfers Fe2+ into the cytoplasm to participate in further cell metabolism. The figure has been adapted from Figure 7 in the article by Wang et al, which begins on page 2216. Professional illustration by Patrick Lane, ScEYEnce Studios.