Figure 5.
Mouse Efl1 mutants model human SDS features. (A) Body sizes of the CH mice (Efl1m/−) at 3 weeks compared with the wild-type littermates. (B) Body weight curves of the CH animals compared with the wild-type animals. Males (left) and females (right) are plotted separately. (C) Survival plot. (D) Hematopoietic features of the CH animals, measured at postnatal days 35-42. (E) Hematoxylin and eosin staining of the bone marrow from 69- and 85-day-old femurs. (F) Level of EFL1 protein in wild-type or CH livers. (G) Immunoblots of eIF6 from wild-type or CH livers. (H) Polysome profiling results of wild-type or CH mouse livers. (I) Quantification of the polysome profiling results. Scale bars, 1 cm (A); 0.5 mm (E).

Mouse Efl1 mutants model human SDS features. (A) Body sizes of the CH mice (Efl1m/−) at 3 weeks compared with the wild-type littermates. (B) Body weight curves of the CH animals compared with the wild-type animals. Males (left) and females (right) are plotted separately. (C) Survival plot. (D) Hematopoietic features of the CH animals, measured at postnatal days 35-42. (E) Hematoxylin and eosin staining of the bone marrow from 69- and 85-day-old femurs. (F) Level of EFL1 protein in wild-type or CH livers. (G) Immunoblots of eIF6 from wild-type or CH livers. (H) Polysome profiling results of wild-type or CH mouse livers. (I) Quantification of the polysome profiling results. Scale bars, 1 cm (A); 0.5 mm (E).

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