Clinical effect of CHIP in the population aged 80 years or older. (A,C) Cumulative probability of overall survival according to the presence of CHIP in subjects aged ≥80 years from the Health_&_Anemia and Monzino_80+ cohorts, respectively. (B,D) Cumulative probability of overall survival according to the number of variants (0 vs 1 vs ≥2) in subjects aged ≥80 years from the Health_&_Anemia and Monzino_80+ cohorts, respectively.