Manhattan plot of pQTL analysis of C5 and complement-related genes adjusted for age, sex, BMI, and VTE status. The dashed lines indicate the genome-wide (top) and C5 cis-region (lower) P-value thresholds for significance. The blue squares mark variants in the ±500 kb cis region around the transcription start/stop of the C5 gene. The purple triangles mark variants in the complement-related genes listed in supplemental Table 2.