Hb and LDH response after the initiation of ibrutinib therapy. Gray lines represent individual data of Hb and LDH; bold line represents median Hb and LDH over time. *Hb decrease at 3 months was considered related to hospital admission for a hip fracture and surgery. †Increased LDH was considered related to the initiation of G-CSF for neutropenia, because other hemolytic parameters were not increased.