Depth of response based on standard and MRD response criteria. PFS (A) and OS (B) of patients stratified according to best response achieved during treatment: MRD⁻, sCR, CR, VGPR, and PR. There were no significant differences in PFS and OS in the comparison of patients achieving sCR, CR, VGPR or PR. PFS was defined as time from best response achieved until disease progression or death from any cause and was estimated by the Kaplan-Meier method. OS was defined as time from best response achieved until death from any cause.