Depth of response based on standard response criteria. PFS of patients achieving sCR, CR, VGPR, and PR after 6 induction cycles of VRD (A); ASCT conditioned with Bu-Mel or Mel-200 HDT (B); or 2 consolidation cycles of VRD (C). PFS was defined as time from response assessment until disease progression or death from any cause and was estimated by the Kaplan-Meier method. OS was defined as time from response assessment until death from any cause. *P < .05; **P < .01; ***P < .001.