Functional enrichment analysis of pathways associated with high-risk immune cell score and the leading edge analysis diagrams. (A) GSEA plots show a significant association between ICSS high-risk and NF-κB, oxidative stress response, and core-enriched HSCs/leukemic stem cells signatures (all P < .01). (B) Diagrams show the log2 fold changes in all the genes studied, highlighting the genes in the leading edge analysis of NF-κB, oxidative stress, and HSC/LSC gene sets.