Biological insights. (A) Heat map of the 200 differentially expressed genes with the lowest adjusted P values ordered by log fold change between pediatric patients with AML with high and low CALCRL expression levels. Rows represent the color-coded genes with blue indicating low, white intermediate, and red high expression values for the given gene. Columns represent patients, ordered from left to right by CALCRL expression. Genes that are mentioned in the text are indicated. The complete list of the 200 most differentially regulated genes can be found in the supplemental Data. (B,C) Event-free survival, (D,E) overall survival, and (F,G) cumulative incidence of relapse according to CALCRL expression in patients with (B,D,F) high and (C,E,G) low LSC17 scores.¹⁷