POW display defective NK cell cytokine training. (A) Heatmap displaying the expression of metabolism-related genes (measured by reverse transcription polymerase chain reaction) in healthy controls (HC; n = 5) and PWO (n = 5). (B-C) Representative dot plot and scatter graph showing impact of NK cells cytokine training on IFN-γ production in cohorts of HC and PWO. Data pooled from a minimum of 5 independent experiments unless otherwise stated. Statistical comparisons using analysis of variance with multiple comparisons. ***P < .001; ****P = < .0001. ns, not significant.