Overall schematic of Markov model with health states and complications. *Minor bleed: required 2 days of treatment at home. This assumption was based on the clotting factor coverage needed for an uncomplicated joint or superficial muscle bleed (as per Lexicomp). It is also aligned with the assumptions used in 2 other hemophilia cost-effectiveness models.^{9,-11 †}Major bleed: required 5 days of hospitalization. This assumption was based on the clotting factor coverage needed for a deep muscle with neuromuscular injury or deep laceration (as per Lexicomp). It is also aligned with the assumptions used in 2 other hemophilia cost-effectiveness models.^{9-11 ‡}Joint damage: development of joint damage started at 8 years of age,^69,70 and eventually the patient required total joint replacement surgery. First surgery was performed at 37 years of age,⁶⁶ and the second and third surgeries (if needed) were performed at 47 and 52 years, respectively. Patients could die at any stage in the model, and this mortality is accounted for by a background mortality rate. Circular arrows indicate that patients could remain in the same health state for multiple consecutive cycles.