Schematic representation of viral integration of a portion of the TTMV gene into intron 2 of the RARA gene. The integration includes TTMV open reading frame 2 (ORF2) and an upstream untranslated region (UTR) adjacent to a short sequence of retained RARA intron 2, in-frame with exon (ex) 3. This integration results in the transcription of a chimeric fusion messenger RNA with a start codon (ATG) at the initiation of TTMV ORF2. This chimeric fusion transcript results in an APL-like gene expression signature and ultimately the development of acute promyelocytic leukemia (APL). Adapted from Figure 1 in the article by Astolfi et al that begins on page 1773.