Frequency, mutational spectrum and clinical correlates of CH in patients undergoing THA. (A) Occurrence of CH with VAF ≥1% in 200 patients. (B) Frequency of CH among different age groups (not showing 1 patient with missing information about age and 1 patient older than age 90 years). (C) Mutation frequency of recurrently mutated genes with VAF ≥1%. Correlation of CHIP with clinical parameters: representation of hemoglobin levels (D) and mean corpuscular volume (MCV) (E) levels according to the absence or presence of CHIP. Red bars showing the prevalence of anemia (hemoglobin <13 g/dL in men and <12 g/dL in women) (F), cardiovascular disease (G), previous or present malignant disease (H), and AID in patients with and without CHIP (I). Unadjusted P values were obtained using Wilcoxon-Mann-Whitney test for continuous variables (D-E) and χ² test for categorical variables (F-I). (J) Multivariable logistic regression analysis ($) per 10-year increase, (¢) female vs male, and (†) per 1 g/dL increase. OR was adjusted for the effects of the other covariates. *P < .05; **P < .01. MCV, mean corpuscular volume.