Proposed regulatory pathways of R4 RGS in HSPCs. The molecular network of RGS1, RGS13, and RGS16 downstream of SDF-1/CXCR4 and Gα_i was generated by MetaCore with the integration of our gene expression and functional data. The red and blue circles represent up- and downregulation of gene expression/protein activity. The green, red, and gray arrows indicate positive, negative, and unspecified interactions between objects, respectively. The effector genes were categorized by functions.