Adjusted mean differences in SF-36 physical and mental health component scores between patients with APL previously treated with ATRA-ATO vs ATRA chemotherapy. The figure represents the differences in mean scores and corresponding 95% CIs, adjusted for time since protocol completion, of physical (A) and mental component summary scales (B) from the SF-36 questionnaire between long-term APL survivors previously treated with ATRA plus arsenic trioxide or ATRA plus chemotherapy. A positive difference in all scales indicates better outcomes in the ATRA plus arsenic trioxide arm than in the ATRA plus chemotherapy arm. A red square indicates a clinically relevant difference.