Targets for adoptive T-cell immunotherapies in cHL. Mechanisms of immune evasion depicted include PD-L1 expression by HRS cells and TAMs, downregulation of MHC (also known as HLA), and secretion of various chemokines and cytokines by HRS cells to recruit Treg cells. Adoptive immunotherapy strategies include CD30 CAR T cells, CD19 CAR T cells, and CD123 CAR T cells, which can be combined with PD1 inhibitors to counteract checkpoint blockade. CCL, chemokine (C-C) ligand; TCR, T-cell receptor.