Figure 1.
Overview of analysis populations for propensity score–balanced and standardized comparisons. (A) Propensity scores were derived to generate a primary and sensitivity common support data set for ZUMA-1 and SCHOLAR-1, which were then used to estimate the average treatment differences in response to and survival for anti-CD19 CAR T-cell therapy and historical standard of care (non–CAR T-cell therapy). (B) Strata by refractory category and postrefractory SCT for standardization are depicted. Standardized analyses were conducted that equally weighted the proportions of patients by refractory categorization and presence of autologous or allogeneic SCT after establishing refractoriness to salvage therapy (postrefractory SCT) in each study.

Overview of analysis populations for propensity score–balanced and standardized comparisons. (A) Propensity scores were derived to generate a primary and sensitivity common support data set for ZUMA-1 and SCHOLAR-1, which were then used to estimate the average treatment differences in response to and survival for anti-CD19 CAR T-cell therapy and historical standard of care (non–CAR T-cell therapy). (B) Strata by refractory category and postrefractory SCT for standardization are depicted. Standardized analyses were conducted that equally weighted the proportions of patients by refractory categorization and presence of autologous or allogeneic SCT after establishing refractoriness to salvage therapy (postrefractory SCT) in each study.

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