Platelet function phenotypes. (A) Heat map resulting from hierarchical clustering of data from cohort 1. Each column represents a response variable, and each row represents a donor. Red cells represent higher responses, and blue cells represent lower responses. (B) Rows are clustered into subgroups. Dendrograms, columns, and rows are assessed by bootstrapping randomizations (Pvclust; n = 10 000). Approximately unbiased > 90 indicates stable clusters. (C) Donors are placed on the plane of the first 2 PCs to highlight subgroup characteristics. The x-axis goes from low responders on the left through to high responders on the right. The y-axis progresses from those donors who have a higher capacity than sensitivity at the bottom through to those with a higher sensitivity than capacity at the top. Subgroups 6 and 5 contain donors that are high responders. Subgroup 6 has donors that have a higher sensitivity than capacity, whereas donors in subgroup 5 have a greater capacity of response than they are sensitive to agonists. Subgroups 4, 3, 2, and 1 are lower responders. Group 3 contains general medium responders and group 2 contains lower responders, whereas group 1 contains donors with a greater sensitivity than capacity, and group 4 are low responders with a greater capacity than sensitivity. Barcodes (displayed for donors D039 and D012) summarize individual donor characteristics.