Cross-comparisons between S63845-sensitive and -resistant cell lines reveal common and cell line–specific combination partners. (A) Correlation analyses of S scores in S63845 sensitive vs resistant cells indicate a strong association between both cell line variants, but also revealed certain key differences. (B) S scores of all 4 screened cell line variants according to selected drug classes that underline common as well as cell line–specific patterns in response to S63845 combination treatments.